The science behind Galectovid

There are over 15,000 medical journals that highlight the role of Galectin-3 in various health conditions. These studies demonstrate that Galectin-3 is not only a biomarker but also a potential therapeutic target for managing inflammation and supporting immune function.

COVID 19

Galectin approach to lower covid transmission -
Drug Development for clinical use

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Alben Sigamani, Kevin H Mayo, Hana Chen-Walden, Surender Reddy, David Platt

The Role of Galectin-3 in Health Conditions

Galectin-3 is a key protein involved in immune system regulation and inflammation. Elevated levels of Galectin-3 are associated with chronic inflammatory conditions, and its inhibition may help support immune responses and reduce inflammation.

Scientific Research on Galectin-3 and Its Impact on Immune Function

Recent studies have explored how Galectin-3 inhibitors may be beneficial for managing various health conditions, including those related to viral infections. For example, ProLectin-M (PL-M), a Galectin-3 antagonist, has been investigated for its ability to modulate immune responses.

Study Overview

In a recent study, PL-M was evaluated in a randomized, double-blind, placebo-controlled trial involving subjects with mild to moderate symptoms related to immune system activation. The study aimed to determine how PL-M influences Galectin-3 and its effects on immune function.

Study Design & Methods

The trial assessed the efficacy of PL-M in 34 subjects, focusing on the modulation of immune markers and inflammation. Primary endpoints included changes in key biomarkers associated with immune system activation. In vitro studies also investigated how PL-M interacts with Galectin-3 and its role in immune modulation.

Results

PL-M significantly improved key immune markers compared to the placebo group, demonstrating its potential to reduce immune system dysregulation and inflammation. These results support the idea that Galectin-3 inhibition can promote a more balanced immune response.

Conclusion‍

PL-M, a Galectin-3 inhibitor, was shown to safely support immune function and manage inflammation. These findings suggest that targeting Galectin-3 may be an effective approach for addressing conditions related to immune system dysregulation and chronic inflammation.

Galectin-3 Research

2021 Translational Study: Galectin-3 in septic acute kidney injury: a translational study 2021 Preclinical Study: Galectin-3 participates in PASMC migration and proliferation by interacting with TGF-β1 2021 Translational Study: A translational study of Galectin-3 as an early biomarker and potential therapeutic target for ischemic-reperfusion induced acute kidney injury 2020 Preclinical Study: Galectin-3 Inhibition Reduces Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation 2020 Review: Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider 2020 Review: A Potential Role for Galectin-3 Inhibitors in the Treatment of COVID-19 2020 Prospective Cohort Study: Gal-3 a Potential Biomarker of Vascular Calcification for Maintenance Hemodialysis (MHD) Patients 2020 Clinical Study: Galectin-3 a Biomarker for the Early Detection of Diabetic Kidney Disease (DKD) 2020 Review and Meta-analysis: Serum Galectin-3 is Associated with Increased Risk of Atrial Fibrillation Recurrence 2020 Preclinical Study: Gal-3 Signaling Pathway is Related to Pathogenesis of Atrial Fibrillation in Diabetes 2019 Preclinical Study: Galectin-3 Blocker Targets Galectin-3-Induced STAT3 Activation to Synergize with Chemotherapy Drug Paclitaxel Against Ovarian Cancer 2019 Preclinical Study: Galectin-3 Inhibition Improves Ischemic Heart Failure by Downregulating Galectin 3 and Reducing Myocardial Fibrosis 2019 Preclinical Study: Blockade of Galectin-3 Prevents Profibrotic and Proinflammatory Effects of Cardiotrophin-1 (CT-1) in Myocardial Fibrosis 2019 Preclinical Study: Blockade of Galectin-3 Prevents Cardiac Damage, Inflammation, and Fibrosis Following Kidney Injury 2019 Preclinical Study: Galectin-3 Inhibitor Reduces the Pro-Inflammatory, Pro-fibrotic, and Pro-osteogenic Response in Aortic valves in Patients Undergoing Aortic Valve Replacement 2019 Preclinical Study: Blockade of Galectin-3 Prevents Cardiac Fibrosis, Inflammation and Functional Alterations

Health Interests

  • Immune Support
  • RSV (Respiratory Syncytial Virus)
  • H1N1 (Influenza A Virus)
  • H5N1 (Avian Influenza Virus)
  • Epstein-Barr Virus
  • Cancer Metastasis
  • Diabetes
  • MASH (Metabolic Associated Steatohepatitis)
  • Stroke
  • Fibrosis
  • Neurological Conditions
  • COVID-19
  • Long COVID

Understanding Galectin-3's Role in Cellular Processes

The interaction between cells and foreign agents is complex, and it’s not always as straightforward as it might seem. Both viruses and cells are covered in sugar molecules, which are crucial for cell recognition and communication. These sugar molecules, called glycans, form unique patterns that help identify different cell types and can change based on the cell’s health.

These glycans act like barcodes, which glycan-recognizing proteins use to communicate with each other and neighboring cells. This communication network helps in various cellular processes, including immune function and inflammation regulation.

This is where Galectin-3, a galactoside-binding lectin, plays a crucial role. Galectin-3 functions as an adhesion molecule, attaching to both cell surfaces and certain proteins that are involved in immune system regulation. Galectin-3 can form structural lattices by binding to itself and other sugars, which is essential for cellular communication and immune regulation.

The Role of Galectin-3 in Immune Response

Galectin-3 plays an important role in cellular interactions that support immune system responses. When there is an overexpression of Galectin-3, it can interfere with immune system regulation, contributing to chronic inflammation and immune system dysregulation.

Galectin-3 inhibitors can potentially disrupt these processes by preventing the excessive binding of Galectin-3 to cells and proteins. This inhibition helps manage immune system overreaction and inflammation by disrupting the pathways that allow foreign agents to interact with host cells, thus supporting better immune function.

The Impact of Galectin-3 on Health Conditions

Research shows that by modulating Galectin-3 levels, it is possible to influence chronic inflammation, immune system balance, and various conditions that result from immune dysregulation. Galectin-3 inhibitors have the potential to support overall health by improving immune responses and managing inflammation more effectively.

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